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isochorismate synthase : ウィキペディア英語版 | isochorismate synthase
Isochorismate synthase (MenF) ((EC number 5.4.4.2 )) is involved in the biosynthesis of vitamin K in ''Escherichia coli''. This enzyme catalyzes the first step in the biosynthesis of menaquinone (vitamin K). == Reaction == Isochorismate synthase is an enzyme that catalyzes the irreversible reaction: Chorismate→ Isochorismate The only subrate of this reaction is chorismate, and the product is isochorismate. Isochorismate synthase is most active at 37℃ and at a pH between 7.5-8. Isochorismate synthase requires Mg2+. The concentration of Mg2+ may range from 100μM-1mM.〔 Inhibitors of isochorismate synthase include:
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